If you don’t get proper sleep when you are young, you’ll be suffering from Alzheimer’s when you are old?

Why do human beings need sleep?
When we’re done with our busy day, our tired body thirsts for rest and sleep. Even though research has pointed out that the brain continues to stay active during sleep, and some people around us have even said that they will still feel energetic everyday with less than 5 hours of sleep, but is that really the case? What functions does sleep have on the human body?

Over the years, there were many theories on the functions of sleep, including wound healing, heat regulation, consolidation of memory, and dreams promoting a creative mind. However, a recent research published by a top scientific journal suggested that sleep might be associated with the prevention of Alzheimer’s disease.

This theory was first brought up by in 2005 by psychologists in St. James Hospital in Dublin. They demonstrated the correlation between sleeping disorders (insomnia, daytime napping) and the degree of dementia in patients suffering from Alzheimer’s disease. This is not strange at all, as many brain diseases are associated with sleep disorders. Therefore, this is considered a very practical knowledge, which assists doctors and caretakers in the selection of appropriate medication for improving sleep quality. However, a lot of people believe that such correlation goes even deeper, with a more complicated mechanism behind it.

In order to understand the connection between sleep and Alzheimer’s disease, some scientists began attempting to replicate the typical example of Alzheimer’s disease in mice. One of the teams, led by David Holtzman of Washington University in St. Louis, demonstrated the correlation between sleep and beta-amyloid concentration, as they discovered that beta-amyloid concentration in mice increased when they stripped away the sleep time of mice. Contrarily, by stimulating sleep through an injection of anesthetic, beta-amyloid concentration would decrease. These researches began in 2009. Afterwards, they further treated the mice with anti-beta-amyloid injections, and the mice went back to normal sleeping patterns as a result. A year later, Maiken Nedergaard of University of Rochester in New York and her team discovered that the brain would flush out metabolic wastes by itself during deep sleep. Specifically, the brain would utilize a network of micro-channels filled with the cerebrospinal fluid to remove the metabolic waste such as beta-amyloid in the brain. This network of channels is called the “glymphatic pathway,” a lymphatic system that is made up of neuroglial cells that is capable of brain waste removal. This discovery is recognized as associated with Alzheimer’s disease.

Next, neuroscientist Matthew Walker of University of California, Berkeley and his team conducted further research. He believes that the connection between sleep and memory is more intimate than what people currently knows. His research discovered that the brain would conduct memory consolidation during NREM sleep, especially during the stage of slow-wave sleep. His research also indicated that those with higher levels of beta-amyloid concentration do not perform well in slow-wave sleep, and the same goes with memory recall. This research emphasized the potential importance of sleep in the treatment of Alzheimer’s disease. However, there are also a few issues that lie with this research, such as the fact that its causality has yet to be determined, or the fact that participants underwent testing in different environments could also affect the explanation of the results.

Even though there are still problems yet to be solved, these researches provided new insights and research directions concerning the relationship between sleep, beta-amyloid, and memory, as well as indicated that there may be complex interactions between the three. The results of these researches provided new possibilities for the treatment and prevention of Alzheimer’s disease.

Although there are still plenty of contradicting perspectives regarding Alzheimer’s disease, there are still evidences, albeit insufficient, which confirm that adopting a non-pharmacological method in treating Alzheimer’s disease still exist.  In any case, it is still essential for us to adopt some proper lifestyle choices cautiously to prevent Alzheimer’s disease.

What happens when you have insomnia? What are some of the ways to improve this disorder?

What is the definition of insomnia? Insomnia is defined as the difficulty of falling asleep or staying asleep repeatedly, which in turn causes the reduction of sleep time and a deterioration of sleep quality. According to diagnostic standard addressed in The Diagnostic and Statistical Manual of Mental Disorders, a person diagnosed with insomnia suffers from sleep difficulty for at least 3 nights in a week and display symptoms such as fatigue, excessive napping, mood fluctuations, difficulty concentrating or physical discomfort, which in turn affects learning or work. For a person suffering from insomnia for less than a month, he/she is suffered from short-term insomnia. If the disorder persists for longer than one month, it is categorized as chronic insomnia. There are three types of insomnia: challenges falling asleep, inability to maintain sleep, and early-morning wakefulness.

Five Most Common Reasons for Insomnia
There are many reasons that causes insomnia, the most common ones include:

1.Psychological factors: overtly worrying, restlessness, overt excited, work anxiety, feeling depressed, excessive pressure and stress; some mental disorders also cause insomnia.
2.Lifestyle: Rotating shifts, smoking, drinking caffeinated or other stimulating beverages before going to sleep.
3.Environmental Factors: Noise, light, mosquito bites, hot weather in the environment can also affect sleep.
4.Physiological Factors: Polyuria, coughing, pain, or sleep apnea.
5.Changes in Biological Clock: Travel, jetlag

If you want to improve insomnia, foods with the following ingredients are recommended for consumption:

Selenium: A lack of selenium can cause abnormal sleep. Selenium is also the key element in the functions of the immune system and the thyroid gland. Foods containing selenium include Brazil nuts, sunflower seeds, beef, oysters, and cremini.

Tryptophan: Tryptophan is a precursor to the secretion of serotonin in the human body. Sources of tryptophan include turkey meat, eggs, sweet potato, chia seeds, banana, pumpkin seeds, almonds, yogurt and green leafy vegetables.

Vitamin B6: Assists with modulating the body’s response to stress, as well as aiding to relax the nervous system. Some of the best sources of Vitamin B6 include banana, sugar-free yogurt, cashew nuts, peanut butter, almonds, avocado, fish, tomatoes, spinach, sweet potatoes, seaweed, and eggs.

Vitamin C: Those with lower concentrations of Vitamin C will have more sleep problems, and will more likely wake up in the middle of the night. Excellent sources of Vitamin C include common foods such as sweet peppers, green leafy vegetables, kiwi fruits, strawberries, citrus fruits and papayas.

Vitamin D: Vitamin D deficiency is significantly correlated with excessive napping during daytime. Bathing in natural sunlight can increase Vitamin D concentration. Some foods, such as swordfish, salmon, tuna, mackerel, shiitake mushrooms, and oysters can also replenish appropriate amounts.

Potassium: Potassium is helpful for those that have a hard time sleeping for an extended amount of time. Bananas are usually considered as the best source of potassium. However, there are better choices: green leafy vegetables, potatoes, broccoli, cremini, and avocado are all excellent potassium-containing foods.

Calcium: Research indicated that disruption of REM sleep (rapid eye movement) is associated with calcium deficiency. Excellent sources of calcium that is useful for the body include curly kale, collard greens, brown mustard, sardines, seaweed, and sesame seeds.

Omega-3 Fatty Acids: Omega-3 fatty acids helps one to attain a better night’s sleep. Consumption of chia seeds, pumpkin seeds, hemp seeds, walnuts, halibut, salmon, flax seeds, or cold-pressed oils like flaxseed oil, fish oil, or krill oil can all increase omega-3 fatty acids intake.

Melatonin: Foods that can naturally increase the melatonin concentration in the body include pineapple, tomato, banana, oranges…etc.

To prevent insomnia or lower the probability of insomnia from occurring, experts have the following recommendations:

1.Go out under the sun for 30 minutes: Being under the sun can effectively adjust one’s biological clock.
2.Do not use any electronic products 30 minutes before going to sleep: The strong light from electronic products will directly enter your eyes, which decreases the secretion of melatonin, delaying sleep or lowers sleep quality. With that said, reading a book before sleep is completely fine, as the light emitted enters the eyes by reflecting off the book, so the intensity of the light is not as strong.
3.Prepare a simple sleep journal. If you have a lot on your mind that causes you unable to sleep, try writing them down. There are also specific rules to when writing them:
You have to write it, not type it or use speech input.
It is recommended to do so in the study room or in the living room, or at least do not write them while on the bed. This is to prevent you from associating the inability to sleep with the bed itself.
Only write for 15 minutes
When writing, just list them out, otherwise you might get increasingly more annoyed.
When 15 minutes is up, close the journal and put it in the drawer even if you did not finish writing. Doing so is to tell yourself to put down your worries.
4.Create a Sense of Ritual: Tell your body you will prepare for rest after completing a certain task. Experts pointed out that brushing your teeth, reading, or changing into pajamas before going to bed are all good methods.
5.Get up and walk around if you can’t sleep, don’t just stay on the bed.
6.Avoid conducting all work-related matters in the bedroom.
7.Avoid intense exercise before going to sleep.
8.Avoid drinking any caffeinated beverages before going to sleep, such as coffee or tea.
9.Avoid eating or drinking water right before going to bed.

A Long Sleep is No Match for A Good Sleep ~ A Brief Discussion on Deep Sleep

As the knowledge of sleep science becomes more well known, everyone knows that the body needs at least 7 ~ 8 hours of sleep every night. Adequate sleep reduces the chances of many physiological illnesses and psychological disorders from happening, such as depression or the three hypers, and can even drastically lower the chances of suffering from neurodegenerative diseases in old age. In other words, sleep just brings a plethora of benefits. However, plenty of people said that they still feel extremely tired in the morning or are still having trouble getting up even when they did get eight hours of sleep, and why is that? Well, the problem may lie in your deep sleep.

What is deep sleep?
To put it in simple terms, deep sleep is a part of the sleep cycle. This is the time when both the brain and the body fall into low activity status. If you are using smart bracelet or sleep detection APPs, you will discover that your RHR, your BPM, and your EEG have all dropped down to the bare minimum during deep sleep, as this is the time when your body is concentrating on secreting growth hormones, repairing tissues and cells, as well as helping your muscles and bone grow. On the psychological aspect, deep sleep assists with the stabilization of your emotions, in addition to releasing all the negative energy within your body.

Sleep at this stage is also called “slow-wave sleep” (α brainwave). Although the brain is still active, the senses of our body perceive the least stimulation from the outside world and we won’t be woken up that easily. At this point, the body is in the repair mode, eliminating all the stress received throughout the day. The toxic wastes that our brain has accumulated throughout the day are also most efficiently removed during this precious repairing period. The anesthetics used during operations will allow the patient go directly into deep sleep, so deep sleep is also the sleep stage that is the hardest to wake a person up from. A regular person will have the hardest time waking up from deep sleep. If you are forcibly woken up from deep sleep, you will feel quite dizzy. Judging from an 8-hour sleep time perspective, deep sleep usually occupies a longer period of time for young people, at approximately 20~25% of the entire sleep time. Deep sleep will occupy less and less time as the age of a person increases, which is why older individuals are more prone to be suffering from inadequate sleeping quality.

If one does not acquire enough deep sleep, the body and the brain will not attain sufficient time to repair and cleanse itself. Therefore, it’s natural for one to wake up still feeling extremely tired and stressed. So how does one maintain sufficient deep sleep? Experts have this to say:

Fixed Sleep Time
Develop a regular routine and never stay up late. Strive towards going to bed before 11 o’clock every night, and sleep for 6~9 hours to increase time for deep sleep, thereby allowing the body to have ample time to secrete hormones to repair body tissues while also replenish the body and nourish the spirit.

Relax the Body Before Going to Sleep
Take a hot bath or a foot bath before going to sleep can facilitate blood circulation in the body, in addition to helping the body relax so that one falls asleep easier. Research has shown that the effect of the hot bath can relax the body and in turn increases time in deep sleep, which aids in the removal of stress and pressure accumulated throughout the day.

Don’t Use Any Electronic Products Before Going to Sleep
A lot of people will use their electronic products before they go to sleep, whether it’s taking care of work matters, scrolling through social media pages, watching shows, or playing games, all of which will stimulate brainwaves. The blue light emitted by electronic products will also stimulate the brain and suppress melatonin, which causes people not want to go to sleep.

Avoid Consumption of Stimulating Foods
Do not drink alcoholic beverages or products which contains caffeine (tea, coffee), which will stimulate the brain and lead to being too stimulated to sleep. Additionally, do not eat spicy foods or foods with a heavy taste as a midnight snack. When hungry, you can consumer hot milk or boiled eggs, which all aids in sleep. Furthermore, it is not ideal to drink water before you go to sleep, as too much water would cause bathroom break(s) in the middle of the night.

Adequate Amounts of Exercise
Research has proven that adequate amounts of exercise during the day increases the duration of deep sleep at night. Additionally, avoid being overweight, as it also affects the quality of sleep. Practice of yoga or other forms of stretching exercises is recommended prior to sleep, as it puts the body in a relaxed state and thereby allowing you to sleep better, falling into deep sleep at a faster rate.

Hope that everyone can adopt the aforementioned tips and be aware of the items you should avoid doing, thereby increasing the duration of deep sleep as well as enhancing sleep quality, feeling energetic and refreshed all day, every day!